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Allergic reactions at night — mild, moderate or 000?

By Dr Kwan Lee 10 May 2026 6 min read
MILDHives only · home careMODERATESwelling · come inSEVEREAnaphylaxis · 000GRADE BEFORE YOU REACT

The 30-second answer

Mild allergic reactions (hives only, no swelling beyond the skin, no breathing change) can usually be managed at home with an oral antihistamine. Moderate reactions (swelling of lips or tongue, generalised itching) need same-night assessment. Any breathing difficulty, voice change, dizziness or collapse is anaphylaxis — use your EpiPen if you have one and call 000 immediately.

Allergic reactions are unusually scary because they can change quickly and they often happen in the evening — after a new food, a new medication, a bite picked up earlier in the day. The good news is that grading them is straightforward once you know the three tiers. The hard part is doing it calmly while it's happening to you.

The three-tier grading

Mild — manageable at home

Action: Take a long-acting antihistamine (cetirizine, loratadine, fexofenadine). Apply a cold compress for itch. Avoid the trigger. Most mild reactions settle within 6 hours.

Moderate — same-night assessment

Action: Take an antihistamine if you can swallow tablets. Walk in to Manningham After-hours Emergency Care or phone us first. We have prednisolone (oral steroid), additional antihistamine, and the equipment to monitor your vital signs and intervene if your reaction escalates.

Severe — call 000 immediately

Any of the following is anaphylaxis:

  • Difficulty breathing, wheeze, noisy breathing or shortness of breath
  • Swelling of the tongue or throat that affects swallowing or breathing
  • Hoarse voice or change in voice
  • Persistent dizziness or fainting
  • Pale and floppy (in young children)
  • Persistent vomiting after a known allergen
  • Collapse or loss of consciousness

If you have an EpiPen, use it now, even if you're not sure. There is no harm in unnecessary adrenaline; there is real harm in delayed adrenaline. Call 000. Lie flat. Stay still.

What anaphylaxis actually looks like

Anaphylaxis has two essential features: it involves more than one body system (skin and breathing, or skin and circulation), and it progresses fast. A simple hives reaction doesn't change much over an hour. Anaphylaxis can go from "I think I'm reacting" to "I can't breathe" in under five minutes.

The mistake people make is waiting to see if the reaction settles. With anaphylaxis, every minute without adrenaline is a minute the airway can swell further. The EpiPen is designed for use during uncertainty.

When an antihistamine is enough

For pure cutaneous (skin-only) reactions, antihistamines work well. Use a non-sedating, long-acting one: cetirizine 10 mg, fexofenadine 180 mg, or loratadine 10 mg. Avoid older sedating antihistamines (promethazine, diphenhydramine) where possible — they can mask deterioration. Take a single dose and reassess in 30 minutes.

When to walk in (we have prednisolone and a calm room)

Walk in to Manningham After-hours Emergency Care for any moderate reaction, particularly if:

We can give a single dose of prednisolone (a fast-acting oral steroid), additional antihistamine, and monitor your observations for an hour. If the reaction escalates while you're with us, we will call an ambulance and transfer you to ED.

Follow-up after an allergic reaction

Anyone who's had a moderate or severe reaction should see their GP within a few days to:

Even mild first-time reactions are worth mentioning to your GP — knowing your triggers prevents recurrences.

Tonight, when you need to decide quickly

Save our number now — it's much easier to call when the decision matters.

Call 0403 025 359

Frequently asked questions

Is swollen lips after eating an emergency?

Lip swelling alone, without breathing change or voice change, is moderate — come in tonight for assessment. Lip swelling plus any breathing or voice change is anaphylaxis — use your EpiPen and call 000 immediately.

How long should hives last?

Mild hives usually settle within 6 to 24 hours with antihistamines. Hives that persist beyond 48 hours, or recur in waves over weeks, are worth seeing a GP about — they may be chronic urticaria with a different cause.

Should I use an EpiPen even if I'm not sure?

Yes. There is no harm in unnecessary adrenaline; there is real harm in delayed adrenaline. If you suspect anaphylaxis, use the EpiPen and call 000. The pen is designed for use during uncertainty.

Can I drive myself to a clinic during an allergic reaction?

For mild reactions, yes. For moderate reactions, have someone drive you if possible. For anything suggesting anaphylaxis, do not drive — call 000 and lie flat while you wait.